近年取得的代表性成果包括:
1. 基于人类多能干细胞,实现了世界首例对着床期人类胚胎发育核心过程的体外重建。通过微制造技术,建立了着床期胚胎组织发育的药物毒性筛查技术。通过与微流控器件的结合,完善了对着床期人类胚胎核心发育过程的体外再现。
2. 设计并发展了亚细胞、细胞、多细胞与组织尺度的生物力学实验技术,揭示了力学在细胞稳态自持、多细胞自组装与形貌调控、干细胞分化等重要生理过程中的关键作用
3. 基于微纳尺度结构的天然生物材料强韧化机理的理论研究
至今已发表SCI论文20余篇,其中包括《Nature Materials》3篇、《Nature Communications》1篇、《Nature》1篇、《Science Advances》1篇、《Advanced Materials》1篇、《Nano Today》1篇、《Journal of Cell Biology》1篇、《JMPS》1篇。相关研究曾被《Nature》、《Nature Materials》、《Journal of Cell Biology》、《麻省理工科技评论》等期刊以专题评论的方式焦点报道,并得到多家专业学术媒体的追踪。基于干细胞的“合成胚胎学”研究成果被《麻省理工科技评论》评选为2018年十大科技突破(与剑桥大学、洛克菲勒大学共同入选)。
代表性论文包括:(*表示共同一作)
[1] Sajedeh Nasr Esfahani*, Yue Shao*, Agnes M. Resto Irizarry, Zida Li, Xufeng Xue, Deborah L. Gumucio, and Jianping Fu. Microengineered human amniotic ectoderm tissue array for high-content developmental phenotyping. Biomaterials, vol. 216, 119244, 2019.
[2] Kenichiro Taniguchi*, Yue Shao*, Ryan F. Townshend, Chari Cortez, Clair Harris, Sasha Meshinchi, Sundeep Kalantry, Jianping Fu, K. Sue O'Shea, and Deborah L. Gumucio. An apicosome initiates self-organizing morphogenesis of human pluripotent stem cells. The Journal of Cell Biology, vol. 216, 3981, 2017.
[3] Yue Shao*, Kenichiro Taniguchi*, Ryan F. Townshend, Toshio Miki, Deborah L. Gumucio, and Jianping Fu. A pluripotent stem cell-based model for post-implantation human amniotic sac development. Nature Communications, vol. 8, 208, 2017.
[4] Yue Shao*, Kenichiro Taniguchi*, Katherine Gurdziel, Ryan F. Townshend, Xufeng Xue, Koh Meng Aw Yong, Jianming Sang, Jason R. Spence, Deborah L. Gumucio, and Jianping Fu. Self-organized amniogenesis by human pluripotent stem cells in a biomimetic implantation-like niche. Nature Materials, vol. 16, 419, 2017.
[5] Shinuo Weng*, Yue Shao*, Weiqiang Chen, and Jianping Fu. Mechanosensitive subcellular rheostasis drives emergent single-cell mechanical homeostasis. Nature Materials, vol. 15, 961, 2016.
[6] Yue Shao*, Jianming Sang*, and Jianping Fu. On human pluripotent stem cell control: The rise of 3D bioengineering and mechanobiology. Biomaterials, vol. 52, 26, 2015.
[7] Weiqiang Chen*, Yue Shao*, Xiang Li, Gang Zhao, and Jianping Fu. Nanotopographical surfaces for stem cell fate control: Engineering mechanobiology from the bottom. Nano Today, vol. 9, 759, 2014.
[8] Yue Shao, Hong-Ping Zhao, and Xi-Qiao Feng. Optimal characteristic nanosizes of mineral bridges in mollusk nacre. RSC Advances, vol. 4, 32451, 2014.
[9] Yue Shao, Jennifer M. Mann, Weiqiang Chen, and Jianping Fu. Global architecture of the F-actin cytoskeleton regulates cell shape-dependent endothelial mechanotransduction. Integrative Biology, vol. 6, 300, 2014.
[10] Yue Shao, and Jianping Fu. Integrated micro/nanoengineered functional biomaterials for cell mechanics and mechanobiology: a materials perspective. Advanced Materials, vol. 26, 1494, 2014.
[11] Yue Shao, Hong-Ping Zhao, and Xi-Qiao Feng. On flaw tolerance of nacre: a theoretical study. Journal of the Royal Society Interface, vol. 11, 20131016, 2014.
[12] Yue Shao*, Xinyu Tan*, Roman Novitski, Misha Muqaddam, Paul T. List, Laura Williamson, Jianping Fu, and Allen P. Liu. Uniaxial cell stretching device for live-cell imaging of mechanosensitive cellular functions. Review of Scientific Instruments, vol. 84, 114304, 2013.
[13] Yue Shao, Hong-Ping Zhao, Xi-Qiao Feng, and Huajian Gao. Discontinuous crack-bridging model for fracture toughness analysis of nacre. Journal of the Mechanics and Physics of Solids, vol. 60, 1400, 2012.
[14] Yue Shao, and Cun-Jing Lu. A direct proof of uniqueness of square-root of a positive semi-definite tensor. Applied Mathematics and Mechanics, vol. 30, 713, 2009.